Investigating a new model of genetic epilepsy

May 19th, 2016|

Grant Announcements 2016: “Individuals who carry mutations in genes that encode receptors activated by the excitatory neurotransmitter, glutamate, can suffer from a variety of disorders, many of which are associated with epilepsy. While our previous research has focused on studying glutamate receptors and their role in neuronal communication, the project funded by ERUK allows us to extend our work to a pre-clinical model that is a direct correlate of epileptic encephalopathy.” Professor David Wyllie

A new approach to blocking seizure networks in temporal lobe epilepsy

May 19th, 2016|

Grant Announcements 2016: “Forward-thinking strategies for the most difficult-to-treat types of epilepsy are desperately needed. I will test whether controlling the activity of entire seizure-generating networks, as opposed to just the seizure foci, can be a more effective treatment to block seizures. To do so, I will use the technology of optogenetics, which has the potential to be translated to the clinic in the coming years, but can also “shine a light” on novel cellular targets to efficiently block seizures for other forms of clinical interventions.” Alfredo Gonzalez-Sulser

Is inflammation in tuberous sclerosis a sign of epileptic activity?

May 19th, 2016|

Grant Announcements 2016: "We are really grateful to Epilepsy Research UK for offering us the possibility of exploring this exciting approach. If the new PET-MRI scanner methods help us find where these patients’ seizures come from, many more patients will be able to undergo surgery in the future.” Professor Alexander Hammers

The link between sleep problems in infants with epilepsy and social and cognitive development

May 19th, 2016|

Grant Announcements 2016: "Our data will indicate whether offering a standard sleep assessment using sleep diaries or actigraphy for newly diagnosed infants would be a low-cost and effective way to avoid cascading consequences of early sleep problems on subsequent socio-cognitive development. Since sleep is a modifiable risk factor, sleep problems could be addressed if picked up early, which could reduce seizure incidence, lead to an increased quality of life of families and save costs.We also aim to communicate the results of our study to caregivers and clinicians as quickly as possible in order to draw their attention onto the importance of sleep in early onset epilepsy." Dr Manuela Pisch

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