Understanding the mechanisms behind mesial temporal lobe epilepsy

Dr Mar Matarin of University College London is looking at the activity (‘expression’) of certain genes in the main cells of both ‘healthy’ and epileptic temporal lobes and hippocampi to gain a better understanding of how these genes normally work and the ways in which their function can be disturbed. She is also trying to find out precisely how different types of cell are affected in mesial temporal lobe epilepsy (mTLE).

Dr Matarin’s research aims to increase our understanding of how mTLE and the accompanying memory/learning impairment develop, and why some people do not respond to anti-epileptic drugs. In the longer term, this knowledge will potentially highlight targets for more effective drug treatments, and possibly enable genetic screening to predict who might be susceptible.

Read more about this research into understanding the mechanisms behind mesial temporal lobe epilepsy here.

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