Restoring learning and memory in temporal lobe epilepsy

Treatment for learning impairment and memory loss in patients with mesial temporal lobe epilepsy (mTLE) is a significant unmet need, and currently there are no effective therapies for this as the underlying neurobiology is poorly understood. New nerve cells are continually being formed in the hippocampus throughout adult life and these are important for forming memory. However the formation of new nerve cells is permanently reduced in chronic TLE, which may explain some of the learning and memory problems frequently experienced by people with mesial temporal lobe epilepsy.

In his research Dr Zaben is working to identify the precise mechanisms which underlie the reduced formation of new nerve cells, and looking at the efficacy of licensed drugs in restoring learning impairments. If successful this research has the potential to have a significant impact on the quality of life of people with mesial temporal lobe epilepsy.

Read more about this research into restoring learning and memory in temporal lobe epilepsy here

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