Important new insights into how seizures begin
The events leading up to a seizure are still not clear and this makes it difficult for scientists to design the most effective anti-epileptic drugs.
Dr Pavlov and colleagues at the Institute of Neurology, University College London are using optogenetic tools that allow them to activate or deactivate identified populations of nerve cells by shining controlled pulses of light on the cells. They are looking at how manipulating the timing and level of activity of different groups of interneurons affects epileptiform activity.
The results of this research will extend our understanding of the cellular and network mechanisms of how seizures begin, and help to develop exciting new approaches to epilepsy treatment.
Read more about this study here.
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