Identifying people who are at risk of SUDEP
Grant round winners 2013 Sudden unexpected death in epilepsy (SUDEP) accounts for approximately 18% of epilepsy-related deaths. There are a number of factors that are thought to increase the risk of SU [...]
The role of autoantibodies in epilepsy
Grant round winners 2012 The immune system is our body’s means of defence against harmful substances (toxins, bacteria, viruses) that manage to enter. One of its roles is to produce antibodies, which a [...]
A new approach to the treatment of absence seizures
Grant round winners 2012 Epileptic seizures occur when the neurons of the brain are hyperexcitable. This is usually prevented by the maintenance of a fine balance between excitation and inhibition in t [...]
Predicting the response to anti-epileptic drug treatment
Grant round winners 2012 Approximately one-third of people with epilepsy do not respond to anti-epileptic drugs (AEDs), and at present there are currently no ways of predicting whether an AEDwill be ef [...]
Restoring learning and memory in temporal lobe epilepsy
Grant round winners 2012 Mesial temporal lobe epilepsy (mTLE) is a common type of focal epilepsy, which affects the hippocampus, parahippocampal gyrus and amygdala of the brain. These structures are lo [...]
Improving the diagnosis of infantile epileptic encephalopathies
Grant round winners 2012 Infantile epileptic encephalopathies (IEEs) include a range of severe epilepsy syndromes, which usually present before the age of 12 months and are associated with intellectual [...]
Understanding the genetics of mesial temporal lobe epilepsy with hippocampal sclerosis
Grant round winners 2012 Approximately two thirds of people with epilepsy have seizures successfully controlled with anti-epileptic drugs (AEDs). The remaining third do not respond to AEDs (they are sa [...]
Understanding brain networks in temporal lobe epilepsy
Grant round winners 2011 Epileptic disorders can be divided into two groups; those that are focal and those that are generalised. In the past it was thought that generalised epilepsy resulted from an a [...]
How do fast brain waves in between seizures come about?
Grant round winners 2011 Approximately two-thirds of people with epilepsy successfully control their seizures with anti-epileptic drugs (AEDs), but for the remaining third, AEDs are not effective (thei [...]
Carbogen for children with non-convulsive status epilepticus
Grant round winners 2011 Status epilepticus can be either convulsive (CSE) or non-convulsive (NCSE) and is defined as a seizure lasting 30 minutes or more, or a series of seizures that occur in success [...]
A better understanding of juvenile myoclonic epilepsy
Grant round winners 2011 Juvenile myoclonic epilepsy (JME) is a common form of generalised epilepsy, which usually presents between the ages of 12 and 18 years and is characterised by myoclonus (involu [...]
Investigating the complications associated with Rolandic epilepsy
Grant awarded in 2011 Rolandic epilepsy (RE) is one of the most common paediatric epilepsy syndromes, affecting approximately 10,000 children in the UK, usually between the ages of 3 and 13. Those affe [...]
