A new tool to investigate epilepsy in Down’s syndrome with Alzheimer’s disease
PILOT GRANT £29,897 over 8 months Awarded in 2013 SCIENTIFIC TITLE A mouse model of seizures in Down’s syndrome/Alzheimer’s disease LEAD INVESTIGATOR Dr Frances Wiseman CO-INVESTIGATORS Prof [...]
Finding out who is at risk of epilepsy after a stroke
Grant round winners 2013 It is widely recognised that having a stroke greatly increases a person’s risk of epilepsy, and statistics show that stroke is the most common cause of epilepsy in people over [...]
A new tool to study epilepsy genetics
Grant round winners 2013 In recent years there has been a growing interest in epilepsy susceptibility genes, and approximately 13 have been identified in humans to date. Susceptibility genes do not nec [...]
Identifying people who are at risk of SUDEP
Grant round winners 2013 Sudden unexpected death in epilepsy (SUDEP) accounts for approximately 18% of epilepsy-related deaths. There are a number of factors that are thought to increase the risk of SU [...]
The role of autoantibodies in epilepsy
Grant round winners 2012 The immune system is our body’s means of defence against harmful substances (toxins, bacteria, viruses) that manage to enter. One of its roles is to produce antibodies, which a [...]
A new approach to the treatment of absence seizures
Grant round winners 2012 Epileptic seizures occur when the neurons of the brain are hyperexcitable. This is usually prevented by the maintenance of a fine balance between excitation and inhibition in t [...]
Predicting the response to anti-epileptic drug treatment
Grant round winners 2012 Approximately one-third of people with epilepsy do not respond to anti-epileptic drugs (AEDs), and at present there are currently no ways of predicting whether an AEDwill be ef [...]
Restoring learning and memory in temporal lobe epilepsy
Grant round winners 2012 Mesial temporal lobe epilepsy (mTLE) is a common type of focal epilepsy, which affects the hippocampus, parahippocampal gyrus and amygdala of the brain. These structures are lo [...]
Improving the diagnosis of infantile epileptic encephalopathies
Grant round winners 2012 Infantile epileptic encephalopathies (IEEs) include a range of severe epilepsy syndromes, which usually present before the age of 12 months and are associated with intellectual [...]
Understanding the genetics of mesial temporal lobe epilepsy with hippocampal sclerosis
Grant round winners 2012 Approximately two thirds of people with epilepsy have seizures successfully controlled with anti-epileptic drugs (AEDs). The remaining third do not respond to AEDs (they are sa [...]
Understanding brain networks in temporal lobe epilepsy
Grant round winners 2011 Epileptic disorders can be divided into two groups; those that are focal and those that are generalised. In the past it was thought that generalised epilepsy resulted from an a [...]
How do fast brain waves in between seizures come about?
Grant round winners 2011 Approximately two-thirds of people with epilepsy successfully control their seizures with anti-epileptic drugs (AEDs), but for the remaining third, AEDs are not effective (thei [...]
