Research Portfolio

Prolonging the experimental lifetime of human epilepsy tissue

May 18th, 2015|

2015 grant: "This research will enable us to maximise the use of living human tissue acquired through epilepsy surgery, which will in turn accelerate the gathering of information about drug-resistant epilepsies. Ultimately it will hopefully lead to the development of more effective drug treatments.” Professor Roland Jones, University of Bath

The link between stress and seizures

July 15th, 2014|

2014 grant: People with epilepsy frequently report emotional stress in the lead-up to a seizure; but although the association between stress and seizures is well recognised, the mechanisms for this is still not understood. Click on the title or picture to read about this pilot grant!

Predicting the response to a first anti-epileptic drug

July 15th, 2014|

2014 grant: The most common type of epilepsy is idiopathic (meaning of unknown cause) generalised epilepsy or IGE. When IGE is first diagnosed is first diagnosed, most people will be treated with an anti-epileptic drug (AED), but only half will find their seizures stop completely in the following year. There are currently no tests to tell neurologists whether a person will respond to AED treatment, and this would be extremely useful. Click on the title or picture to read about this pilot grant!

A potential new treatment for childhood epilepsy

July 15th, 2014|

2014 grant: EEG-biofeedback is a non-invasive learning strategy that can enable a person to alter his/her brain wave activity. It has already been shown to be a safe and effective therapeutic option for some adults with epilepsy, but as yet there are no data available for children. Here Mrs Parker and colleagues will assess the feasibility of using EEG-biofeedback as a therapeutic tool in children with BCECTS. Click on the title or picture to read about this pilot grant!

Identifying side effects of epilepsy drug treatment in people with learning disability

July 15th, 2014|

2014 grant: Epilepsy is more common in adults with learning disability than in the ‘general population’, and there is concern amongst professionals and carers about the physical and behavioural side effects of anti-epileptic drug (AED) treatment in this group. However, it is unclear how best to identify and measure these side effects and their impact on wellbeing. Click on the title or picture to read about this project grant!

Are new methods as good as traditional ones in assessing the neurodevelopmental outcomes of anti-epileptic drug exposure before birth?

July 15th, 2014|

2014 grant: For women with epilepsy pregnancy requires very careful planning, because several anti-epileptic drugs (AEDs) have been shown to increase the chance of birth defects in the unborn child. Exposure to certain AEDs before birth can also have effects upon a child’s behaviour and development, but the nature of these is not fully understood and further research is needed. Click on the title or picture to read about this project grant!

Why does SUDEP happen and can it be prevented?

July 15th, 2014|

2014 grant: The underlying mechanisms of SUDEP are not fully understood, but with more than 500 people in the UK dying in this way each year, it is a serious cause for concern. Click on the title or picture to read about this project grant!

Cutting-edge techniques to explore brain cell activity in epilepsy

July 15th, 2014|

2014 grant: Focal neocortical epilepsy (in which seizures arise in a specific part of the neocortex – the brain’s folded surface) is often resistant to anti-epileptic drugs, and there is an urgent need for new treatment strategies. Click on the title or picture to read about this fellowship award!

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