Research Portfolio

Investigating a new model of genetic epilepsy

May 16th, 2016|

Grant winner 2016: “Individuals who carry mutations in genes that encode receptors activated by the excitatory neurotransmitter, glutamate, can suffer from a variety of disorders, many of which are associated with epilepsy. While our previous research has focused on studying glutamate receptors and their role in neuronal communication, the project funded by ERUK allows us to extend our work to a pre-clinical model that is a direct correlate of epileptic encephalopathy.” Professor David Wyllie

A new approach to blocking seizure networks in temporal lobe epilepsy

May 16th, 2016|

Grant winner 2016: “Forward thinking strategies for the most difficult to treat types of epilepsy are desperately needed. I will test whether controlling the activity of entire seizure generating networks, as opposed to just the seizure foci, can be a more effective treatment to block seizures. To do so, I will use the technology of optogenetics, which has the potential to be translated to the clinic in the coming years, but can also “shine a light” on novel cellular targets to efficiently block seizures for other forms of clinical interventions” Alfredo Gonzalez-Sulser

Transplanting human nerve cells to treat epilepsy

May 16th, 2016|

Grant winner 2016: “This is an exciting project that will give significant insights into the feasibility of cell transplantation for treating seizures and cognitive problems in patients with temporal lobe epilepsy.” Professor Liam Gray

Is inflammation in tuberous sclerosis a sign of epileptic activity?

May 16th, 2016|

Grant winner 2016: We are really grateful to Epilepsy Research UK for offering us the possibility of exploring this exciting approach. If the new PET-MRI scanner methods help us find where these patients’ seizures come from, many more patients will be able to undergo surgery in the future.” Professor Alexander Hammers

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