A new study has provided fresh insight into the optimal dosing strategy for lamotrigine, a commonly-prescribed antiepileptic drug.Led by Tel Aviv University and the Hebrew University of Jerusalem, the research examined the best dosage option for lamotrigine when used on its own in the treatment of adults with complex partial seizures.During the investigation, the records of 188 ‘eligible’ people who had been treated with lamotrigine between 2011 and 2014 were evaluated for a range of information, including dosage levels, treatment efficacy, side effects and retention rates. The findings are published in the medical journal Brain and Behavior.Of the study participants, 77% were found to have continued their lamotrigine treatment, and the average effective dose was found to be 250 mg or higher. Benefits were shown to be more pronounced in subjects over the age of 30 years, and in those who had lived with their epilepsy for five years or more.The researchers conclude that it may be appropriate to reach a daily lamotrigine dose above 250 mg in adults experiencing epilepsy for more than five years, using lamotrigine as an individual therapy.Lamotrigine is marketed under the brand name Lamictal and has been used in the treatment of epilepsy for more than two decades.Click here for more articles about anti-epileptic drugs and pregnancy risks.