The benefits of intravenous lacosamide for the treatment of epilepsy have been demonstrated by a new study.Led by the University Hospital Schleswig-Holstein in Germany, the non-interventional study was conducted to evaluate the efficacy and tolerability of intravenous lacosamide under routine conditions in daily clinical practice.A total of 119 patients with various types of seizure or epilepsy syndrome were recruited by 16 neurological and neuropaediatric centres across Germany and assessed for their response to treatment with the antiepileptic drug (AED).Each patient was observed for ten days, with daily documentation of administration, type and frequency of seizures, currently used drugs and doses, and adverse events. Using this data, the researchers were able to assess the efficacy, tolerability and handling of the treatment.According to results published in the medical journal Seizure, 66.1 per cent of the patients were experiencing focal epilepsy and 17.4 per cent generalised epilepsy, with the nature of the condition deemed to be unclassifiable in 16.5 per cent of cases. The most common causes of seizures were tumours and cerebrovascular diseases.Reasons for using the intravenous AED treatment included preparation for surgery, the presence of convulsive and non-convulsive status epilepticus or the onset of a series of seizures, as well as gastrointestinal causes and acute seizures.In 45 of 64 patients experiencing status epilepticus of a series of seizures, epileptic activity ceased during the observation period. Five patients showed abnormalities in electrocardiogram scans (ECG) taken prior to the infusion and one patient showed a similar result afterwards, but no abnormalities were reported during the actual infusion process.Treating physicians rated the efficacy and tolerability of lacosamide to be very good or good in 77.6 per cent and 93.1 per cent of patients, respectively.The researchers concluded: “This large and independent multicentre registry on the use of intravenous lacosamide in clinical practice demonstrates that intravenous lacosamide is well-tolerated and highly efficacious when given in emergency situations, including patients experiencing status epilepticus. Caution advises to perform ECG diagnostics prior to intravenous lacosamide administration.”Posted by Steve LongClick here for more articles about anti-epileptic drugs and pregnancy risks.