For cases of newly diagnosed epilepsy it is often difficult to determine which antiepileptic drug will be the best treatment option where monotherapy is the aim.At the moment Simona Lattanzi and colleagues of the Marche Polytechnic University in Ancona, Italy believe that current approaches do not provide “sufficient data to select an optimal agent as monotherapy for particular patient requirements and tolerance ….. There is little evidence of how AEDs should be chosen, and practice recommendations are mostly empirical” they indicated.The investigators conducted a network meta-analysis (NMA) as a possible method for selecting an optimal AED for monotherapy in newly diagnosed focal epilepsy. They describe the NMA as a new technique which could offer an objective comparison of alternative treatments when no direct comparisons are available.  If you would like to read more about this piece of research, then you can use the link here: